Table 1 WHO diagnostic list for single organ disease phenotypes associated with CFTR mutations².

Isolated obstructive azoospermia*

Chronic pancreatitis*

Allergic bronchopulmonary aspergillosis*

Disseminated bronchiectasis*

Diffuse panbronchiolitis*

Sclerosing cholangitis*

Neonatal hypertrypsinogenaemia

*At least one CFTR mutation identified.

It is likely that this classification will need further revision in the future as our knowledge and understanding of these conditions increase.²