Table 3 New reports of respiratory symptoms and prevalence of COPD at SAPALDIA 2 in formerly asymptomatic participants with and without BHR at SAPALDIA 1.

Symptoms developed between surveys	Asymptomatic at baseline		p value
	No BHR (n = 3439)	BHR (n = 492)
Physician‐diagnosed asthma (%)	2.0	5.7	<0.001
Wheeze in last 12 months without cold (%)	3.4	8.3	<0.001
Shortness of breath while walking (%)	11.9	19.1	<0.001
Chronic cough (%)	2.3	5.9	0.002
Chronic phlegm (%)	4.8	4.9	0.964
COPD* (%)	14.3	37.9	<0.001

*COPD was defined as FEV₁/FVC <0.70 and no physician's diagnosis of asthma.