Table 2. Structural effect prediction of disease mutations using SDM, negative ΔΔG refers to destabilizing mutation, while positive ΔΔG means stabilizing.

Residues	Location	Clinical mutation	Predicted effect pseudo ΔΔG (kcal/mol)
R57	αB	G	−3.662
C123	β7	R	−0.651
R178	Loop between αD and αE	Deletion