Table 1.

p27^Kip1 expression in normal human tissues

Tissue	Staining
Skin	Labeling in all adnexal structures, including eccrine and sebaceous glands; in epidermis there is labeling in most supra basal cells with increasing intensity as maturation increases; occasional dermal fibroblasts show nuclear staining.
Smooth muscle	Occasional cells stain (gut, erector pili, and around vessels)
Blood vessels	Smooth muscle and most endothelial cells
Lymph node	Many lymphocytes and macrophages in paracortical (T cell areas); occasional cells in germinal centers stain (this is a highly proliferative area, but usually some cells are not cycling); the mantle zone is moderately stained
Spleen	As lymph node with many cells in both white and red pulp staining
Brain	Almost all glial cells stain but neurones do not
Stomach	Occasional cells show nuclear staining but there is no clearly defined pattern seen
Small intestine	Occasional stromal cells in the lamina propria stain; on the epithelium there are occasional cells labeling and most are in the differentiated non proliferative populations of the villus
Colon	Occasional stromal cells in the lamina propria stain; on the epithelium there are occasional cells labeling
Liver	Scattered hepatocytes and Kuppfer cells
Gall bladder	Scattered epithelial cells and most stromal cells
Pancreas	Islets of Langerhans are stained and occasional acinar cells; rare duct cells stain
Salivary gland	Most acinar cells and very occasional duct cells
Lung	Cartilage cells and other stromal cells stain; occasional epithelial cell
Thyroid	Nearly all cells stain in follicles
Breast	Pre- and postmenopausal normal breast very similar; most myo-epithelial cells stain and occasional duct and acinar cells
Cervix	Similar to skin (see above)
Endometrium	Proliferative phase: occasional glandular cells and most stromal cells; secretory phase: infrequent glandular cells, most stromal cells
Fallopian tube	Many epithelial cells and most stromal and smooth muscle cells
Ovary	Occasional stromal cells and most follicle lining cells
Testis	Spermatogonia and Sertoli cells stain
Vas deferens	Only smooth muscle, not epithelium
Prostate	Most myoepithelial cells and glandular epithelium as well as most stromal cells
Kidney	No tubules stain but scattered cells in mesangium and glomerulus
Bladder	Similar to stratified squamous epithelium with increased staining in superficial layers