Figure 3.

Comparison of integrated diet-induced increases in serum (A) and urine (B) AGE levels between groups of diabetic patients (DM) and normal subjects (NL), as well as among groups of diabetic patients with different degrees of renal disease (none, micro-AU, macro-AU, or renal failure; RF) after a single meal of AGE- or CL-diet. Data are expressed as the mean AUC in serum (AGE units/ml × 48 hr), or in urine (AGE units × 10³ per 48 hr). Significant P values are indicated by asterisk (∗, P < 0.05; ∗∗, P < 0.01). Numbers in parenthesis indicate number per group. (C) Correlation by regression analysis of urinary Ccr (ml/min) to the renal excretion of diet-derived AGE. Urine concentration of AGEs is expressed as total area under the curve of AGEs over 48 hr (AUC AGE units × 10³ per 48 hr) (r = 0.73, P < 0.05, n = 17).