Figure 2.

GAD67 knockout mice and cleft palate. (A) Lateral view of wild-type (Left) and GAD67 −/− mutant (Right) newborn mice (P0.5). In homozygous mutants the abdomen is distended but milk is not observed in the stomach. (B) Ventral view of the upper jaw of wild-type (Left) and GAD67 −/− mutant (Right) newborns. Cleft palate (arrows in B and D) was observed in all homozygous mutants. (C and D) Coronal sections of E17.5 facial region of wild-type (C) and GAD67 −/− (D) mice. n, Nasal septa; p, palate; t, tongue.