Figure 5.

Effect of phosphorothioate oligodeoxynucleotides SdC28 and #2 on established tumor growth in a mouse model of human glioblastoma. Treatments were initiated 7 days after implantation of GBM-18 cells. Results are plotted as the tumor volume over time for each treatment: (○), PBS; (⧫), oligodeoxynucleotide #2; (•), DC101; (▪), oligodeoxynucleotide SdC28. A statistical analysis of a regression of the data points for each animal group over time (regressed line not shown on graph) showed that the rate of tumor growth (slope of each regression) for SdC28 and mAb DC101 was significantly different from the PBS control (P < 0.001).