Thymidine ARG of tissue recombinants consisting of wt-S + wt-E (a and b), wt-S + ko-E (c and d), ko-S + wt-E (e), and ko-S + ko-E (f). Grafts were grown for 1 month in female nude mouse hosts, and then hosts were ovariectomized and injected 1 week later with either 100 ng of E2 (a, c, e, and f) or oil vehicle (b and d).