Table 2.
Baseline functional parameters in control and transgenic hearts
| Hearts | Developed tension, g | Heart rate, beats⋅min−1 | +dT/dt, g⋅s−1 | Coronary resistance, mmHg⋅ml−1⋅min−1⋅g−1 |
|---|---|---|---|---|
| Intrinsic heart rate | ||||
| Control (n = 9) | 1.59 ± 0.18 | 318 ± 14 | 30.0 ± 1.4 | 5.92 ± 0.65 |
| Transgenic (n = 10) | 1.18 ± 0.10* | 248 ± 10* | 28.6 ± 1.6 | 6.41 ± 0.43 |
| Electrically paced at 6 Hz | ||||
| Control (n = 9) | 1.61 ± 0.11 | 360 | 32.1 ± 1.5 | 6.32 ± 1.13 |
| Transgenic (n = 11) | 1.56 ± 0.10 | 360 | 32.8 ± 1.7 | 7.59 ± 1.45 |
Functional parameters were measured after 30 min of normal aerobic perfusion at a perfusion pressure of 80 mmHg. Diastolic tension was adjusted to 1.0 g in both groups. All values are means ± SEM. ∗, P < 0.05 transgenic vs. control hearts.