Table 3. Pharmacokinetics of oseltamivir following 75-mg BID for five days administered alone or when coadministered with 100-mg amantadine BID for five days (N = 17).
| PK Parameters for Oseltamivir | N | Geometric Means | Ratio of Geometric Means | 90% Confidence Intervals | ||
| Oseltamivir alone | Amantadine + Oseltamivir | Oseltamivir alone | Amantadine + Oseltamivir | Amantadine + Oseltamivir/Oseltamivir alone | ||
| Cmax (ng/mL) | 17 | 17 | 60.2 | 51.1 | 0.85 | 0.73, 0.99 |
| AUCtau (ng.hr/mL) | 17 | 17 | 161.3 | 148.6 | 0.92 | 0.86, 0.99 |
| Clast (ng.hr/mL) | 17 | 17 | 1.7 | 1.6 | 0.95 | 0.79, 1.14 |