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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Mol Cell Neurosci. 2007 Aug 15;36(4):462–471. doi: 10.1016/j.mcn.2007.08.003

Figure 7. Many of the commissural axon-associated growth cones in Math1/L1 embryos display a swollen/bulbous morphology typically associated with a stalling behavior.

Figure 7

(A, B) Photomicrographs of DiI-labeled axons in open book preparations derived from E12.5 Math1/L1 embryos. (A) This particular open-book preparation contains examples of both swollen/bulbous, stalled growth cones (black arrowheads) and commissural axons tipped by wild type-like growth cones (white arrows) that inappropriately turn into the longitudinal plane on the ipsilateral side of the FP. (B) In this open-book preparation, there are at least four examples of presumably stalled growth cones (black arrowheads). In each panel, the dashed lines demarcate the position of the FP. Ipsi, ipsilateral; ant, anterior direction. Scale bar in (B), 25 μm (A, B).