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. 2007 Dec 12;2(12):e1297. doi: 10.1371/journal.pone.0001297

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Panel A, SCEs were assayed in BrdU labeled, giemsa-stained chromosome spreads from control or RECQ1 siRNA treated HeLa cells. A representative spread is shown for spontaneous SCEs in control and RECQ1-depleted cells. Panel B, Quantitative representation of the number of SCEs per metaphase, either spontaneous or induced by CPT or MMC in cells treated with either control or RECQ1 siRNA. A minimum of 25 metaphases were counted for each cell type and treatment.