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. Author manuscript; available in PMC: 2007 Dec 5.
Published in final edited form as: Mutat Res. 2007 May 18;625(1-2):62–71. doi: 10.1016/j.mrfmmm.2007.05.004

Figure 5. Effects of WY-14,643 on expression of Suv39h1, Suv4−20h2, and PRDM/Riz1 histone methyltransferases in mouse liver.

Figure 5

Liver tissue lysates were separated by SDS-PAGE and subjected to immunoblotting using specific antibodies against Suv39h1, Suv4−20h2, and PRDM/Riz1 histone methyltransferases. Equal sample loading was confirmed by immunostaining against β-actin. Bar graph shows quantitative evaluation (percent change, mean±S.D.) of the Suv39h1, Suv4−20h2, and PRDM/Riz1 expression in livers of WY-14,643-treated mice (n=5 for each time point) relative to those in control animals (all time points, n=15). Representative Western immunoblot images from two independent experiments are shown for each protein. Asterisks (*) indicate significant difference from time/strain-matched control mice.