Figure 1.

Effects of EGb 761 on body growth and survival of Tat transgenic mice. Wild-type and Tat transgenic mice (21 days of age) were injected intraperitoneally with Dox (80 mg/kg/day) for 7 days followed by oral administration of EGb 761 (100 mg/kg/day) for an additional 21 days. EGb 761 was dissolved in PBS, and PBS was included as the vehicle control. Mouse body weight (A) and survival (B) were monitored on a weekly basis. There were seven randomly assigned mice in each group at the beginning of experiments. The body weight was presented for each individual mouse (A), whereas the survival rate was presented for each group (B).