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. 2007 Dec;171(6):1923–1935. doi: 10.2353/ajpath.2007.070333

Figure 6.

Figure 6

Effects of GFAP gene knockout on development of Tat transgenic mice and activation of macrophages/microglia. Twenty-one-day-old mice of C56BL/6 wild-type (Wt), Tat transgenic (Tat), GFAP-null, and GFAP-null/Tat transgenic (GFAP-null/Tat) were treated with Dox only for 7 days (80 mg/kg/day) (Dox), distilled water for 7 days (dW), Dox for 7 days followed by EGb 761 (100 mg/kg/day) for 7 days (Dox + EGb), or Dox for 7 days followed by PBS for 7 days (Dox + PBS). A: Body weight was monitored on a daily basis and calculated for net weight changes at the end of each treatment. At the end of each treatment, mouse brains were harvested and processed for immunohistochemistry staining for Iba-1-positive cells. B: The cell counting was performed within the hippocampal region of the brain using stereology.