Table 2.
Overview of the Expression of Aβ Receptors in Vessels of Control, AD, and HCHWA-D Brains, and Their Association with CAA and SPs in These Brains
| Vessels in control, AD, and HCHWA-D brains
|
CAA Leptomeningeal and parenchymal vessels | SPs Classic | Diffuse | ||||
|---|---|---|---|---|---|---|---|
| Leptomeningeal vessels | Medium-sized parenchymal vessels | Capillaries | Astrocytes | ||||
| APP | + | + | − | + | − | + | − |
| MDR1 | − | + | + | − | − | − | − |
| RAGE | − | + | − | + | + | − | − |
| LRP-1 | + | + | − | + | + | + | − |
| Megalin | − | − | − | + | − | + | − |
| CD36 | + | + | − | + | + | + | − |
| FPRL1 | − | − | − | + | − | + | − |
| LDLR | + | + | + | + | + | − | − |
Expression of Aβ receptors in various brain vessels and in cerebral amyloid angiopathy (CAA) and diffuse senile plaques (SPs) in Alzheimer’s disease (AD) and hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D). The presence of Aβ receptors staining in a specific vessel or lesion is indicated as follows: absent (−), present (+).