Table 3 Association between mean daily dose of inhaled corticosteroid and adrenal insufficiency.
| Mean daily dose of ICS (μg) | Cases (n = 154) | Controls (n = 870)* | OR (95% CI) | OR adjusted for OCS (95% CI)† | ||
|---|---|---|---|---|---|---|
| N | % | N | % | |||
| 0 | 132 | 85.7 | 830 | 95.4 | Reference | Reference |
| <600 | 6 | 3.9 | 21 | 2.4 | 1.6 (0.6 to 4.1) | 0.6 (0.2 to 2.3) |
| 600.1–1200 | 10 | 6.5 | 15 | 1.7 | 4.6 (1.9 to 10.2) | 2.5 (1.0 to 6.2) |
| >1200.1 | 6 | 3.9 | 3 | 0.3 | 13.3 (13.3 to 53.9) | 3.7 (0.7 to 19.2) |
| p value for trend | <0.001 | 0.036 | ||||
ICS, inhaled corticosteroid; OCS, oral corticosteroid.
*One missing data point.
†Adjusted for number of courses of oral corticosteroids per year.