Table 4 SOD3 C+760G (Arg213Gly) exonic polymorphism allele and genotype frequency in COPD patients, resistant smokers, and blood donor controls.
| Groups (% genotyped) | Allele frequencies (%) | Genotype frequencies (%) | |||
|---|---|---|---|---|---|
| C | G | CC | CG | GG | |
| Smokers with COPD N = 222 (97% of total) | 439 (99%) | 5 (1%) | 217 (98%) | 5 (2%) | 0 (0%) |
| Resistant smokers N = 203 (97% of total) | 387 (95%) | 19 (5%) | 185 (91%) | 17 (8%) | 1 (1%) |
| Blood donor controls N = 189 (99% of total) | 369 (98%) | 9 (2%) | 182 (96%) | 5 (3%) | 2 (1%) |
Allele frequency: G v C for resistant smokers compared with the COPD group: OR 4.3 (95% CI 1.5 to 13.3), χ2 = 8.6; uncorrected p = 0.004 (Bonferroni corrected p = 0.016).
Genotype frequency: CG/GG (co‐dominant model) v CC for resistant smokers compared with the COPD group: OR 4.2, 95% CI 1.4 to 13.3), χ2 = 7.8; uncorrected p = 0.005 (Bonferroni corrected p = 0.02).