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. 2006 Oct 13;62(2):147–152. doi: 10.1136/thx.2006.061952

Table 2 Characteristics of the reviewed studies of non‐specific bronchial hyper‐reactivity.

Year Setting Agent Subjects at follow‐up Follow‐up (months) Agent(s) Cut‐off value (mg) Country Reference
1982 Clinic Colophony 20 29 Histamine PC20 16 Europe Burge6
1982 Clinic Red cedar 33 42 Methacholine PC20 24 Canada Chan‐Yeung7
1984 Clinic Isocyanates 12 25 Bethanechol PC15 NS Europe Paggiaro8
1985 Clinic Crab 31 12 Histamine PC20 ⩽16 Canada Hudson9
1985 Clinic Various 32 25 Histamine PC20 ⩽16 Canada Hudson9
1987 Clinic Isocyanates 12 30 Acetylcholine PC15 ⩽0.1 Europe Rosenberg12
1987 Clinic Isocyanates 21 48 Histamine, cold air PC10 NS Europe Lozewicz10
1988 Clinic Isocyanates 30 10 Methacholine PD20 Europe Mapp13
1988 Clinic Crab 31 64 Histamine, methacholine PC20 ⩽16 Canada Mapp43
1988 Clinic Red cedar 16 47 Methacholine PC20 ⩽16 Canada Chan‐Yeung14
1989 Clinic Various 21 28 Histamine PC20 ⩽16 Canada Allard15
1989 Workplace Aluminium 43 60 Methacholine PC20 ⩽8 New Zealand O'Donnell16
1989 Clinic Various 23 70 Histamine PC20 ⩽16 Canada Allard 15
1990 Clinic Isocyanates 10 22 Methacholine PD15 ⩽1 Europe Paggiaro44
1992 Clinic Isocyanates 6 6 Methacholine PD20 ⩽1.4 Europe Saetta18
1992 Workplace Aluminium 12 23 Methacholine PC20 ⩽16 Europe Soyseth17
1993 Clinic Isocyanates 9 48 Methacholine PD20 ⩽1 Europe Paggiaro45
1994 Workplace Platinum salts 24 19 Methacholine PC50 (SGaw) ⩽8 Europe Merget24
1994 Clinic Cobalt 8 36 Methacholine PD15 ⩽1 Europe Pisati23
1995 Clinic Isocyanates 10 13 Methacholine PD20 ⩽1.4 Europe Saetta25
1996 Clinic Various 15 40 Methacholine PC20 ⩽16 Canada Grammer46
1997 Clinic Isocyanates 35 24 Methacholine PC20 (extrapolation) Korea Park30
1998 Clinic Various 42 37 Methacholine PC20 ⩽16 Europe Perfetti47
1998 Clinic Various 33 107 Methacholine PC20 ⩽16 Europe Perfetti47
1998 Workplace Isocyanates 6 240 Histamine PC20 ⩽16 Europe Barker48
2002 Clinic Latex 16 56 Histamine PC20 ⩽16 Europe Vandenplas36
2002 Clinic Isocyanates 41 67 Methacholine PC20 (extrapolation) Korea Park37
2004 Clinic Various 103 104 Methacholine PC20 ⩽16 Canada Maghni40

NS, not significant; PC, previously calcified; PD, previously demineralised.