Table 1.

Observed nucleotide frequency at randomized positions in 76 independent samples of molecules cleaved inefficiently by Fpg

5′ … CAGAGT	N	N	N	N	8-oxoG	N	N	N	N	TGACAG … 3′
A	38	27	28	24	3	45	30	31	27
G	10	28	30	26	56	7	21	14	26
C	17	11	10	14	4	14	11	12	11
T	11	10	8	12	13	10	14	19	12
χ2*	36.7	20.0	28.0	10.3	130.7	64.1	14.8	15.1	15.6
P	<0.001	<0.001	<0.001	<0.025	<0.001	<0.001	<0.005	<0.005	<0.005

^*χ² and P values are for deviation from a random distribution of 0.25 for each of the four nucleotides.