Table 2.

In vitro-selected sequence contexts for inefficient and efficient cleavage of 8-oxoG by Fpg

	Consensus	O	E	χ2	P
Inefficient cleavage consensus,	5′ (N)A	45	19	35.6	<0.001
n = 76	5′ (N)ARAR	12	1.2	98.5	<0.001
	5′RRRR (N)	17	4.8	31.6	<0.001
	5′RRRR (N)A	9	1.2	51.4	<0.001
Efficient cleavage consensus,	5′ (N)YC	1	9.5	7.6	<0.01
n = 76	5′ Y(N)K	4	19	11.8	<0.001
	5′ YY(N)	4	19	11.8	<0.001

Listed sequences are for the strand that originally contained the lesion (N). Following convention, R = purine, Y = pyrimidine, and K = G or T.