Table 2 Long‐term outcome after median 9 years in comparison with trial data of 61 juvenile idiopathic arthritis patients who participated in a randomised placebo‐controlled sulfasalazine trial13*.
Variable | Trial baseline | End of trial (24 weeks) | Follow‐up (median 9 years) | Differences between end of trial and follow‐up p value |
---|---|---|---|---|
General assessments | ||||
Active joints (range 0 to 71) | 5 (3 to 11) | 2 (1 to 7) | 2 (0 to 6) | NS |
Limited joints (range 0 to 67)† | 4 (1 to 7) | 2 (1 to 5) | 5 (2 to 12) | <0.001 |
Physician's score of disease activity (range 0 to 5)‡ | 3 (3 to 4) | 2 (1 to 3) | 2 (1 to 3) | NS |
Erythrocyte sedimentation rate mm/h | 27 (11 to 43) | 11 (6 to 22) | 8 (5 to 22) | NS |
C‐reactive protein mg/l | 6 (1 to 29) | 2 (1 to 11) | 2 (1 to 6) | NS |
No. (%) of patients with | ||||
No active joints | 0 | 14 (23%) | 16 (26%) | NS |
No limited joints | 6 (10%) | 9 (15%) | 6 (10%) | NS |
>4 active joints | 36 (59%) | 20 (33%) | 18 (30%) | NS |
>4 limited joints | 26 (43%) | 18 (30%) | 33 (54%) | <0.001 |
*Values are given in median and interquartile range (IQR 25 to 75%) or number and percentage as indicated; †limited joints = joints with limitation in range of motion;17 ‡PGAS: 0 = none; 1+ = very low; 2+ = low; 3+ = moderate; 4+ = active; 5+ = very active.