Table 3 Odds ratios for four disease‐risk association models and the hypothesised protective D70 allele.

Risk factor	OR	95% CI	p Value
SE	2.09	1.77 to 2.48	<0.001
DR4	2.29	1.88 to 2.78	<0.001
Non DR1‐SE	2.43	1.98 to 2.97	<0.001
DR1‐SE	1.15	0.89 to 1.47	NS
D70	0.72	0.60 to 0.86	<0.001

NS, non‐significant; SE, shared epitope.

*No homozygosity effect found.

All models tested were additive, so ORs represent differential RA risk per copy of the evaluated allele.

D70 analysis was controlled for presence of the shared epitope.