Table 4 Odds ratios for HLA‐DRB1 SE association with five RA‐related disease phenotypes, controlled for age, gender, and duration of RA.

Phenotype	OR	95% CI	p Value
Comorbid Sjogren	0.98	0.79 to 1.21	NS
Joint replacement	1.47	1.08 to 2.00	0.016
Morning stiffness	0.94	0.74 to 1.21	NS
Rheumatoid nodules	1.71	1.35 to 2.16	<0.001
Radiographic change	1.54	1.13 to 2.11	<0.001

HLA, human leucocyte antigen; NS, non‐significant; RA, rheumatoid arthritis; SE, shared epitope.

All ORs were calculated for an additive genetic model, and so reflect increased risk of exhibiting the phenotype per additional SE allele.

Radiographic change denotes documented bone erosion or periarticular osteopenia in any joint.