Table 2 Symptoms and treatment of treatment limiting infusion reactions.

Symptom	No. of patients	Pharmacological treatment	No. of patients	Premedication and other prophylactic measures	No. of patients
Shortness of breath/chest pressure	21	Hydrocortisone intravenous	12	Clemastine (intravenous or per os)	21
Flush	16	Clemastine	17	Steroid (hydrocortisone intravenous)	20
Urticaria	15	Betamethasone	11	Initial slow infusion rate	10
Pruritus	10	Oxygen	4	Paracetamol/acetaminophen	1
Swelling of face	6	Hydration with saline	6	Loratadine	1
Shivers/cold sweat	5	Epinephrine	4	Diazepam	1
Nausea/vomiting	3	Diazepam	3	Prednisolone	1
Hypotension	2	Cetirizine	1	Hydration with saline	1
Tachycardia	2	Prednisolone	1
Increased pain from the joints	2
Light‐headededness	1	Non‐pharmacological treatment
Cough	1	Stopped infusion	43
Headache	1	Lowered infusion rate	4
Increased swelling of the joints	1
Increased intracranial pressure (feeling of)	1
Muscular spasms	1