Table 2 Frequency of chondrocalcinosis in hip or knee joints by HFE genotypes.
| HFE genotypes | Age ⩽65 years | Age >65 years | ||||
|---|---|---|---|---|---|---|
| n | Percent | Odds ratio (95% CI)† | n | Percent | Odds ratio (95% CI)† | |
| C282Y | ||||||
| Non‐carriers | 469 | 4.5 | 1.0 (reference) | 516 | 7.4 | 1.0 (reference) |
| Heterozygotes | 74 | 2.7 | 0.7 (0.1 to 2.9) | 60 | 8.3 | 1.2 (0.1 to 3.3) |
| Homozygotes | 2 | 0.0 | – | 2 | 0.0 | – |
| H63D | ||||||
| Non‐carriers | 372 | 4.0 | 1.0 (reference) | 434 | 6.9 | 1.0 (reference) |
| Heterozygotes | 146 | 4.1 | 1.1 (0.4 to 2.8) | 147 | 10.2 | 1.8 (0.9 to 3.5) |
| Homozygotes | 14 | 21.4 | 4.7 (1.2 to 18.5)* | 19 | 0.0 | – |
*p = 0.02 for comparison with non‐carriers; †OR, odds ratios compare the frequency of chondrocalcinosis among subjects heterozygous or homozygous for the C282Y or H63D variants with that of non‐carriers, calculated using logistic regression analysis after adjustment for age and gender.
CI, confidence interval. n, number of subjects.