Table 3 Number of hand joints with osteophytes, joint space narrowing or radiographic osteoarthritis (ROA) by HFE genotypes†.
| HFE genotypes | Osteophytes | Joint space narrowing | ROA‡ | |||||
|---|---|---|---|---|---|---|---|---|
| ⩽65 years | >65 years | ⩽65 years | >65 years | ⩽65 years | >65 years | |||
| n | n | |||||||
| C282Y | ||||||||
| Non‐carriers | 590 | 5.0±0.3 | 534 | 6.3±0.4 | 1.4±0.1 | 1.6±0.2 | 2.4±0.5 | 3.3±0.4 |
| Heterozygotes | 78 | 5.5±0.6 | 71 | 5.8±0.7 | 1.9±0.3 | 1.2±0.4 | 2.3±0.4 | 2.6±0.6 |
| Homozygotes | 3 | 5.3±2.5 | 3 | 2.3±4.9 | 0.2±1.5 | 2.3±3.0 | – | 3.6±4.2 |
| H63D | ||||||||
| Non‐carriers | 466 | 4.4±0.3 | 446 | 4.7±1.6 | 1.0±0.1 | 2.0±1.0 | 2.0±0.2 | 3.5±1.4 |
| Heterozygotes | 184 | 5.2±0.4* | 142 | 4.7±1.7 | 1.2±0.2 | 1.6±1.0 | 2.4±0.3 | 3.2±1.4 |
| Homozygotes | 18 | 6.1±1.0 | 18 | 4.9±2.0 | 2.8±0.5** | 1.5±1.2 | 4.4±0.7** | 2.8±1.7 |
*p = 0.03, **p = 0.01 for comparison with non‐carriers; †figures are means±standard errors, calculated using univariate linear regression analysis after adjustment for age and gender; ‡ROA was diagnosed for any joint with a Kellgren score 2 or higher.
n, number of subjects.