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. 1998 Jul 21;95(15):8648–8653. doi: 10.1073/pnas.95.15.8648

Figure 5.

Figure 5

Examination of candidate genes for telomere length regulation. (A) Chromosomal localization of Terf1, Terf2, Tert, and Tep1. The segregation of these genes among flanking genetic loci on mouse chromosomes 1, 8, 13, and 14 in [(C3H/HeJ-gld × M. spretus) F1 × C3H/HeJ-gld] interspecific backcross mice is shown. Filled boxes represent the homozygous C3H pattern and open boxes represent the F1 pattern. The number of mice with each haplotype is shown in each column. The mapping of the reference loci as well as the relationship to other mouse chromosomal markers is available on the internet: http://www.informatics.jax.org/crossdata.html to enter DNA Mapping Panel Data Sets from MGI (Mouse Genome Informatics), then select the Seldin cross and Chromosome. The consensus map positions derived from interpolation on the most recent composite maps (http://www.informatics.jax.org/bin/ccr/current/index) indicate the following map positions: Terf1 at 11.8 cM on mouse chromosome 1, Terf2 at 50 cM on mouse chromosome 8, Tert at 49 cM on mouse chromosome 13, and Tep1 at 18.9 cM on mouse chromosome 14. (B) χ2 analysis of genotyping results of microsatellite markers for candidate genes and chromosomal regions. The genotypes of long and short telomere mice are shown (SS, homozygous M. spretus genotype; BS, heterozygous BALB/c and M. spretus genotype or C57BL/6J and M. spretus genotype). Note that the results for the X-chromosome show segregation distortion or pseudo-segregation distortion consistent with other studies in similar interspecies crosses (28). (C) Haplotype analysis of distal mouse chromosome 2 in 28 short telomere mice. Each column corresponds to the observed haplotype pattern with the typing results for each marker indicated by either filled (homozygous M. spretus) or open (heterozygous genotype) boxes. The number of mice observed with each haplotype is shown at the bottom of each column. The approximate chromosomal position of each microsatellite marker on each chromosome based on the most recent consensus map is shown adjacent to each marker.