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. 2007 Dec 15;21(24):3244–3257. doi: 10.1101/gad.1588507

Figure 6.

Figure 6.

NF-κB controls cell cycle exit and gene expression signature of aging in parallel but not in sequential pathways. (A) NF-κB inhibition in young mice induces epidermal proliferation without affecting gene expression signature of aging. (Left) Average relative gene expression (±SD) of the aging signature (genes that are induced by age and reversed by NF-κB blockade from Fig. 4C) in young and old K14:NFKB1ΔSP-ER mice. P-value shows significant difference between old EtOH and old 4-OHT (Student’s t-test). (Right) Ki-67 protein expression and epidermal thickness before and after 4-OHT treatment. Bar, 30 μm. (B) Enforced cell cycle entry by MYC does not induce the aging signature. Shown is the average relative gene expression (±SD) of the aging signature 1 or 4 d after 4-OHT treatment in young K14:MYC-ER mice. (C) TPA-enforced hyperproliferation in old skin has little effect on the aging signature. Gene expression and Ki67 staining are as above. (D) Model of NF-κB action in aging. Accumulation of NF-κB activity with age imparts additional layers of age-specific functions. Upon NF-κB blockade in aged tissue, multiple features characteristic of aging are reversed.