Table 1.
Tissue | Mice | Age, days | Sex | Total pfu* | No. of mutants | Mutation frequency, ×10−4 | Mutation frequency, 100% clonality† |
---|---|---|---|---|---|---|---|
I. Thymic lymphoma | A | 115 | F | 138,820 | 211 | 15.2 | 13.9 |
B | 121 | F | 234,760 | 759 | 32.3 | 24.2 | |
C | 139 | F | 214,460 | 447 | 20.8 | 19.0 | |
D | 132 | F | 207,740 | 581 | 28.0 | 25.6 | |
E | 123 | F | 211,620 | 1729 | 81.7 | 44.9 | |
F | 81 | M | 210,140 | 1105 | 52.6 | 32.4 | |
Mean | 38 ± 23‡ | 27 ± 10 | |||||
II. Normal thymus | G | 19 | F | 295,020 | 166 | 5.6 | 2.6 |
H | 19 | F | 300,460 | 89 | 3.0 | 2.6 | |
I | 26 | M | 281,640 | 155 | 5.5 | 4.0 | |
Mean | 5 ± 1.2 | 3 ± 0.7 | |||||
III. Normal thymus | J | 132 | F | 185,100 | 109 | 5.9 | |
K | 103 | M | 249,180 | 104 | 4.2 | ||
Mean | 5 ± 0.8 | ||||||
IV. Normal brain | E | 123 | F | 220,080 | 89 | 4.0 | |
F | 81 | M | 215,300 | 95 | 4.4 | ||
Mean | 4 ± 0.2 |