Table 2.

lacI mutation spectrum of Msh2^−/− thymic lymphomas (I) and Msh2^−/− normal thymi (II)

Animal	Transitions GC → AT AT → GC	Transversions GC→TA GC→CG AT→TA AT→CG	Frameshifts, +1 or −1 nucleotide	Insertion/deletion, >1 nucleotides	No. of mutations	Clonality, %*
I. Msh2−/− thymic lymphomas
A	16/17† (3/3 CpG)	3/3	3/4	0	22/24	8
B	9/11 (2/4 CpG)	0	5/8	1/1	15/20	25
C	6/7 (1/1 CpG)	1/1	3/3	0	10/11	9
D	4/5 (2/3 CpG)	4/4	3/3	0	11/12	8
E	8/17 (2/4 CpG)	2/2	1/1	0	11/20	45
F	3/3 (1/1 CpG)	4/4	1/6	0	8/13	38
Total	46/60 (11/16 CpG)	14/14	16/25	1/1	77/100	23
Distribution of independent mutations‡	60% (24% CpG)§	18%	21%	1%	100%
II. Msh2−/− normal thymi
G	8/20 (3/15 CpG)	1/1	1/1	0	10/22	54
H	9/11 (2/3 CpG)	2/2	4/4	1/1	16/18	11
I	6/6 (1/1 CpG)	6/11	1/1	0	13/18	28
Total	23/37 (6/19 CpG)	9/14	6/6	1/1	39/58	33
Distribution of independent mutations	59% (26% CpG)	23%	15%	3%	100%

*Clonality = number of clonal (total-independent) mutations/total number of mutations. 

^†n/m = n independent mutations of m mutations found. 

^‡Based on numbers of independent mutations. 

^§Number of independent transitions occurring at CpG sites per total number of independent transitions.