Figure 2.

Histological analysis (hematoxylin–eosin staining) of paraffin-embedded lung sections from mice after i.v. injection of cells expressing the different Ras effector domain mutants. Diffuse metastatic fibrosarcoma tumor tissue (T) can be observed in the lungs of mice injected with cells expressing either wt V12 Ras (B) or V12S35 Ras (C) but not in those injected with cells expressing either control vector (A), V12G37 Ras (D), or V12C40 Ras (E), the lungs from which were completely free of metastatic lesions 14 weeks post injection. (Bars = 100 μm.)