Figure 1.

Urinary nitrite plus nitrate excretion is increased in p53 KO mice. Wt p53 (■) and p53 KO (×) mice were treated with C. parvum (100 mg/kg at day 0) or the same volume of 0.9% NaCl [wt p53 (♦), p53 KO (▴)], and daily urine samples were collected (four mice per treatment group). The total urinary nitrite plus nitrate excretion of C. parvum-treated p53 KO mice was approximately 200% higher than the output of wt p53 mice. Although urinary nitrite plus nitrate excretion of wt p53 mice returned to baseline levels after 14 days, p53 KO mice maintained an elevated excretion throughout the 28 days of urine collection.