Figure 6.

AdExTek inhibits the growth of spontaneous lung metastasis. Primary tumors (4T1) grown in the footpad were surgically removed after reaching 5 mm in diameter. At the same time, the animals were divided into two groups: one group was injected i.v. with control virus AdPacβ-gal (n = 7), and the other group was injected i.v. with AdExTek virus (n = 10). Animals were sacrificed 25 days after removal of the primary tumor. The lungs were weighed and fixed in Bouin’s solution, and lung surface metastases were counted (B). Lung weight increase (A) was calculated as described in Methods. Data are plotted as mean ± SE.