Table 1.

Summary of the β-catenin gene mutations in mouse and human hepatocarcinomas

Deletions	Mouse			Human
	PK/c-myc	WHV/c-myc	PK/H-ras	Samples	Cell lines§
m exon 2 (aa 12-37)*	1/30
m exon 2 (aa 19-74)*	1/30
m exon 2 (aa 5-80)*†	9/30	2/20	3/11
m exons 2-4 (aa 22-172)*	1/30
m exons 2-5 (aa 32-249)*			1/11
h exons 3-4 (aa 25-140)*					HepG2
h exons 3-4 (aa 20-151)*				1/26
	Point mutations
		D32N		D32V, D32Y
	S33C, S33Y	S33F
	G34V	G34V (2)‡, G34E		G34E	G34V(HuH6)
	S37P	S37F		S37Y
	T41A	T41I (2)‡
				S45P
Total mutations	17/30	10/20	4/11	6/26	2/5

The exon encoding the GSK-3β phosphorylation site is exon 2 for the mouse (m) and exon 3 for human (h). 

^*Amino acid deleted according to mRNA analysis. 

^†m exon 2 encodes aa 5-80 in the mouse β-catenin gene. 

^‡Mutations detected on two independent tumors. 

^§The different cell lines tested were the HepG2, HuH6, PLC/PRF/5, Hep3B, and Huh7.