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. 1998 Jul 21;95(15):8858–8863. doi: 10.1073/pnas.95.15.8858

Figure 1.

Figure 1

Reduced apoptosis and rescued hair growth defect in K5 E2F1 transgenic mice lacking p53. (A) Skin section from a line 1.0 transgenic mouse with wild-type p53 was subjected to a TUNEL assay by using fluorescein-dUTP. Several brightly stained nuclei can be seen in the epidermis. (B) Skin section from a line 1.0 transgenic mouse null for p53 was subjected to a TUNEL assay. (C) A line 1.0 male mouse heterozygous for p53 was mated with a p53 heterozygous female. The genotypes of resultant siblings pictured are, from left to right: K5 E2F1 positive, p53+/+; K5 E2F1 positive, p53+/−; K5 E2F1 positive, p53−/−; K5 E2F1 negative, p53−/−.