Table 1.
Spontaneous skin tumors in K5 E2F1/p53-deficient mice
| Mouse | Line | p53 status | Age, wk | Site | Histological appearance |
|---|---|---|---|---|---|
| 1 | 1.1 | p53+/− | 35 | Neck | w.d. SCC |
| 42 | Leg | Keratoacanthoma | |||
| 42 | Face | BCC | |||
| 2 | 1.1 | p53+/− | 46 | Face | w.d. SCC |
| 3 | 1.1 | p53+/− | 39 | Back | p.d. SCC |
| 39 | Back | BCC | |||
| 4 | 1.1 | p53+/− | 41 | Flank | BCC |
| 41 | Abdomen | p.d. SCC | |||
| 5 | 1.1 | p53+/− | 41 | Back | w.d. SCC |
| 6 | 1.1 | p53+/− | 36 | Side | p.d. SCC |
| 36 | Chest | p.d. SCC | |||
| 7 | 1.0 | p53+/− | 21 | Back | m.d. SCC |
| 8 | 1.0 | p53+/− | 20 | Head | p.d. to m.d. SCC |
| 20 | Mouth | Ameloblastoma | |||
| 9 | 1.0 | p53+/− | 39 | Head | m.d. SCC |
| 10 | 1.0 | p53+/− | 24 | Back | m.d. SCC |
| 26 | Leg | p.d. SCC | |||
| 11 | 1.0 | p53+/− | 20 | Back | m.d. SCC |
| 12 | 1.0 | p53+/− | 24 | Back | w.d. SCC |
| 34 | Leg | BCC | |||
| 36 | Flank | p.d. SCC | |||
| 13 | 1.0 | p53+/− | 29 | Back | m.d. to p.d. SCC |
| 14 | 1.0 | p53+/− | 32 | Flank | m.d. to p.d. SCC |
| 33 | Back | p.d. SCC | |||
| 15 | 1.0 | p53+/− | 30 | Flank | p.d. SCC |
| 30 | Head | Spindle cell carcinoma | |||
| 16 | 1.0 | p53+/− | 27 | Back | BCC |
| 17 | 1.0 | p53+/− | 18 | Back | Tricoepithelioma |
| 18 | 1.0 | p53+/− | 26 | Back | p.d. SCC |
| 19 | 1.0 | p53−/− | 15 | Mouth | p.d. SCC |
| 20 | 1.0 | p53−/− | 9 | Groin | p.d. SCC |
| 21 | 1.0 | p53−/− | 14 | Back | p.d. SCC |
Age is in weeks at time of tumor detection. Site is where on the skin the tumor was detected. w.d., well differentiated; m.d., moderately differentiated; p.d., poorly differentiated.