Figure 1.

Scanning electron micrographs of primary breast cancer cells. (A) Low magnification overview showing a part of tissue fragment of the breast cancer biopsy and the cells with epithelial and fibroblast-like morphology which migrate out from it. (B) Higher magnification of the boxed area in figure 1A exhibiting the mixed cell population that has grown out from tissue fragment consisting of spindle shaped fibroblasts (arrows) and polygonal astrocytic epithelial cells (double arrows).(C) Epithelial-like cells of breast cancer primary culture appearing flat with a relatively smooth surface and well-formed cytoplasmic extensions (arrow). (D) A large number of epithelial-like breast cancer cells which are well attached to the substrate of the glass cover slip and with well developed filopodial extensions forming stratified layers. In the majority of the cells prominent nuclei with numerous nucleoli are clearly observed.