Table 5 CL 20% lower than CL reported by Piitulainen et al6.
Dosage regimen | Mean exogenous AAT CminSS | 5th percentile | 95th percentile |
---|---|---|---|
60 mg/kg/7 days | 1.13 (1.37) | 0.51 (0.75) | 2.05 (2.29) |
50 mg/kg/7 days | 0.94 (1.18) | 0.43 (0.67) | 1.70 (1.94) |
120 mg/kg/14 days | 0.50 (0.74) | 0.20 (0.44) | 1.02 (1.26) |
180 mg/kg/21 days | 0.40 (0.64) | 0.17 (0.41) | 0.79 (1.03) |
250 mg/kg/28 days | 0.24 (0.48) | 0.10 (0.34) | 0.51 (0.75) |
Mean total AAT CminSS shown in parentheses.