Table 3 Genome‐wide linkage analysis for bronchodilator responsiveness in all subjects, non‐smokers and smokers only.

Phenotype*	Subjects	Covariates	Chromosome	cM	LOD	p Value
BDRbase	All	None	4	70	1.26	0.008
	Non‐smokers	None	10	31	1.59	0.002
	Smokers	Gender	16	66	1.31	0.019
BDRpred	All	None	9	49	1.25	0.007
	Non‐smokers	None	10	31	1.69	0.002
	Smokers	Gender	16	66	1.22	0.018
BDRabs	All	None	9	49	1.53	0.003
	Non‐smokers	None	9	49	1.72	<0.001
	Smokers	Gender	16	66	1.60	0.012

The maximum LOD score for each analysis is reported. Full results are available in supplementary table 3.

*Definitions of BDR phenotypes⁷:

BDRbase = (FEV_{1post‐bronchodilator}‐FEV_{1pre‐bronchodilator})/FEV_{1pre‐bronchodilator} ×100%.

BDRpred = (FEV_{1post‐bronchodilator}‐FEV_{1pre‐bronchodilator})/FEV_1predicted ×100%.

BDRabs = (FEV_{1post‐bronchodilator}‐FEV_{1pre‐bronchodilator}).

All three BDR variables were log₁₀ transformed for analysis.