Table 3.
IL-4 effect on HIV-1 mutant molecular clones
| Virus | p24 (ng/ml)
|
Induction | |
|---|---|---|---|
| IL-4 (−) | IL-4 (+) | ||
| NL4-3 | 31.3 | 72.3 | 2.3× |
| tat(−) | 1.5 | 1.5 | 1× |
| Rev(−)RRE(−) | 5.2 | 10.7 | 2× |
| nef(−) | 27.1 | 59.6 | 2.2× |
Phytohemagglutinen-stimulated PBMC were infected with the different HIV-1 mutant molecular clones. Supernatants for cell-free infection were obtained from transfected 293 cells. Values represent p24gag concentrations in culture supernatants at 5 days postinfection. Similar results were obtained in three independent experiments using cells from different donors.