Table 3 Effect of C‐reactive protein (CRP, mg/l) on lung function using linear regression in two cross‐sectional studies of the Nottingham Lung Health Study population in 1991 and 2000.
| 1991 (n = 2425) | 2000 (n = 1298) | |
|---|---|---|
| FEV1 (ml) | –9 (–13 to –5) | –7 (–13 to –2) |
| Stratified by smoking status | ||
| Never | –6 (–10 to –1) | –3 (–11 to +4) |
| Ex | –27 (–39 to –15) | –13 (–22 to –4) |
| Current | –9 (–20 to +2) | –5 (–28 to +17) |
| pinteraction = 0.005 | pinteraction = 0.494 | |
| Stratified by gender | ||
| Male | –13 (–21 to –6) | –5 (–14 to +4) |
| Female | –5 (–9 to –1) | –10 (–17 to –4) |
| pinteraction = 0.022 | pinteraction = 0.342 | |
| Stratified by BMI (kg/m2) | ||
| >20 | –28 (–60 to +4) | –77 (–247 to +94) |
| 20–24.9 | –16 (–25 to –7) | +4 (–6 to +14) |
| 25–29.9 | –12 (–19 to –5) | –6 (–14 to +2) |
| >30 | –3 (–10 to +5) | –20 (–31 to –10) |
| pinteraction = 0.015 | pinteraction = 0.033 | |
| FVC (ml) | –11 (–16 to –7) | –8 (–14 to –2)* |
| Stratified by smoking status | ||
| Never | –9 (–14 to –3) | –4 (–13 to +4) |
| Ex | –31 (–45 to –18) | –14 (–24 to –4) |
| Current | –7 (–18 to +5) | –10 (–36 to +16) |
| pinteraction = 0.003 | pinteraction = 0.459 | |
| Stratified by gender | ||
| Male | –18 (–27 to –10) | –5 (–15 to +5) |
| Female | –5 (–11 to 0) | –12 (–19 to –5) |
| pinteraction = 0.001 | pinteraction = 0.437 | |
| Stratified by BMI (kg/m2) | ||
| <20 | –20 (–53 to +13) | –102 (–285 to +80) |
| 20–24.9 | –18 (–28 to –8) | +4 (–8 to +16) |
| 25–29.9 | –16 (–24 to –8) | –7 (–16 to +3) |
| >30 | –4 (–11 to +4) | –26 (–39 to –13) |
| pinteraction = 0.025 | pinteraction = 0.029 |
FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; BMI, body mass index.
Basic model using FEV1 adjusted for sex, age, age2, height, age‐height, body mass index and magnesium intake, smoking status (categorical) and smoking pack‐years.
*1297 individuals provided data for analysis.