Table 3 Statistical comparison of biomarkers in patients with COPD and controls.
| Sequence | Protein ID | Controls | COPD patients | T ratio | FDR_p | p Value | ||
|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | |||||
| 1 | MMP‐9 | 4129.05 | 1524.12 | 6298.61 | 2437.93 | 5.07 | 0.00028 | 0.00000 |
| 2 | Eotaxin‐2 | 3821.17 | 2786.26 | 6897.35 | 4303.97 | 4.37 | 0.00078 | 0.00003 |
| 3 | MMP‐7 | 860.72 | 340.62 | 1431.51 | 1021.53 | 4.37 | 0.00078 | 0.00003 |
| 4 | MMP‐10 | 1111.17 | 445.91 | 1813.39 | 1424.64 | 4.54 | 0.00078 | 0.00002 |
| 5 | TARC | 178.84 | 124.23 | 386.29 | 541.28 | 4.44 | 0.00078 | 0.00002 |
| 6 | TNF‐α | 83.24 | 19.97 | 112.99 | 48.21 | 4.40 | 0.00078 | 0.00003 |
| 7 | BDNF | 293.34 | 347.45 | 992.07 | 1348.16 | 4.17 | 0.00106 | 0.00007 |
| 8 | GCP‐2 | 100.41 | 26.19 | 131.26 | 45.91 | 4.16 | 0.00106 | 0.00007 |
| 9 | MIF | 702.08 | 165.77 | 1062.19 | 931.81 | 4.15 | 0.00106 | 0.00007 |
| 10 | NE | 3951.64 | 925.28 | 4917.56 | 1284.20 | 4.18 | 0.00106 | 0.00006 |
| 11 | IL‐1‐sR1 | 173.18 | 89.25 | 264.36 | 157.92 | 4.04 | 0.00144 | 0.00011 |
| 12 | MMP‐8 | 7479.60 | 5112.69 | 14511.88 | 9305.13 | 4.00 | 0.00151 | 0.00013 |
| 13 | TIMP‐1 | 2885.88 | 1477.78 | 4677.85 | 2424.25 | 3.91 | 0.00197 | 0.00018 |
| 14 | AR | 117.76 | 30.93 | 146.85 | 47.46 | 3.77 | 0.00253 | 0.00029 |
| 15 | IL‐10rβ | 689.21 | 200.70 | 874.60 | 287.25 | 3.70 | 0.00253 | 0.00037 |
| 16 | IL‐12p40 | 130.59 | 41.13 | 162.29 | 54.10 | 3.69 | 0.00253 | 0.00037 |
| 17 | IL‐1rα | 176.72 | 53.05 | 221.43 | 61.74 | 3.80 | 0.00253 | 0.00026 |
| 18 | IL‐2rβ | 275.40 | 92.33 | 366.01 | 155.99 | 3.73 | 0.00253 | 0.00033 |
| 19 | IL‐8 | 209.52 | 80.41 | 278.40 | 101.25 | 3.79 | 0.00253 | 0.00027 |
| 20 | I‐TAC | 86.84 | 51.75 | 138.41 | 95.26 | 3.71 | 0.00253 | 0.00036 |
| 21 | VEGF | 127.21 | 40.98 | 168.05 | 65.40 | 3.70 | 0.00253 | 0.00036 |
| 22 | VEGF‐D | 263.56 | 142.27 | 361.02 | 186.09 | 3.56 | 0.00377 | 0.00058 |
| 23 | CD30 | 158.85 | 69.99 | 210.88 | 102.48 | 3.48 | 0.00457 | 0.00077 |
| 24 | Eotaxin | 235.07 | 80.48 | 282.00 | 65.23 | 3.49 | 0.00457 | 0.00075 |
| 25 | MCP‐1 | 633.02 | 303.92 | 936.95 | 584.67 | 3.44 | 0.00496 | 0.00087 |
| 26 | IL‐1α | 91.98 | 31.06 | 113.74 | 38.44 | 3.41 | 0.00508 | 0.00096 |
| 27 | Prolactin | 925.25 | 244.88 | 1274.07 | 838.37 | 3.42 | 0.00508 | 0.00093 |
| 28 | TNF‐R1 | 525.09 | 455.95 | 800.09 | 616.36 | 3.35 | 0.00597 | 0.00117 |
| 29 | IL‐1β | 98.21 | 34.65 | 124.21 | 53.06 | 3.31 | 0.00662 | 0.00134 |
| 30 | BLC | 192.76 | 89.61 | 294.84 | 240.72 | 3.29 | 0.00675 | 0.00142 |
| 31 | FGF‐4 | 347.42 | 95.24 | 434.21 | 169.61 | 3.26 | 0.00719 | 0.00156 |
| 32 | MPIF‐1 | 624.64 | 331.03 | 825.75 | 398.73 | 3.17 | 0.00932 | 0.00209 |
| 33 | IGFBP‐4 | 6118.33 | 1188.73 | 7136.63 | 2703.80 | 3.15 | 0.00962 | 0.00222 |
| 34 | CTACK | 3480.02 | 1367.85 | 4745.23 | 3090.78 | 3.12 | 0.01005 | 0.00239 |
| 35 | HCC‐1 | 1201.77 | 352.24 | 1549.81 | 870.31 | 3.07 | 0.01130 | 0.00276 |
| 36 | Eotaxin‐3 | 229.35 | 114.73 | 609.19 | 2006.73 | 3.06 | 0.01138 | 0.00291 |
| 37 | IL‐17 | 343.13 | 69.30 | 390.90 | 84.96 | 3.05 | 0.01138 | 0.00302 |
| 38 | TGF‐α | 210.31 | 107.82 | 595.09 | 2168.58 | 3.05 | 0.01138 | 0.00299 |
| 39 | MIP‐1δ | 2094.72 | 836.45 | 2878.11 | 1762.62 | 2.99 | 0.01326 | 0.00362 |
| 40 | EGF | 158.28 | 64.86 | 216.59 | 164.16 | 2.93 | 0.01458 | 0.00428 |
| 41 | M‐CSF | 78.34 | 24.86 | 96.89 | 35.82 | 2.93 | 0.01458 | 0.00422 |
| 42 | Protein C | 8112.46 | 1788.08 | 9087.41 | 1603.96 | 2.94 | 0.01458 | 0.00412 |
| 43 | HCC‐4 | 8572.51 | 2501.97 | 10071.78 | 2581.08 | 2.90 | 0.01498 | 0.00461 |
The protein markers were filtered by false discovery adjusted p‐value (FDR_p) of 0.015. The FDR adjusted p value (sometimes called just FDR) is a practical way of dealing with multiple testing issues and can be interpreted as estimated proportion of false positives in the list. The T ratio was computed from common log scale. The names of all the analytes are given in the online supplement available at http://thorax.bmj.com/supplemental.