Table 3 Multivariate associations between patient characteristics and infectivity, drug resistance and treatment adherence: OR (95% CI) with p values.
| Laboratory findings | Management issues | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sputum smear positive | Any drug resistance | MDRTB | Isoniazid resistant (non‐outbreak) | Isoniazid resistant (outbreak) | Non‐adherent in first 2 months | Loss to follow‐up within 6 months | DOT from start of treatment | DOT ever | |
| Age 0–14 | 0.3 (0.1 to 0.8) | 1.0 (0.3 to 3.4) | 0.8 (0.2 to 4.6) | 0.6 (0.2 to 1.4) | 0.6 (0.8 to 4.7) | 9.2 (3.3 to 25.6) | 8.2 (3.2 to 20.6) | ||
| Age 15–29 | 1.3 (1.0 to 1.7) | 1.1 (0.8 to 1.6) | 1.1 (0.7 to 1.7) | 1.2 (0.9 to 1.7) | 1.7 (1 to 2.9) | 0.8 (0.5 to 1.4) | 1.0 (0.8 to 1.3) | ||
| Age 30–59 | 1 (p = 0.008) | 1 (p = 0.22) | 1 (p = 0.41) | 1 (p = 0.32) | 1 (p = 0.24) | 1 (p<0.001) | 1 (p<0.001) | ||
| Age 60+ | 0.7 (0.4 to 1.3) | 0.6 (0.4 to 1.0) | 0.5 (0.3 to 1.2) | 1.1 (0.8 to 1.6) | 1.2 (0.5 to 2.9) | 1.8 (0.8 to 3.7) | 2.7 (1.7 to 4.4) | ||
| Male | 1.1 (0.8 to 1.5) (p = 0.38) | 1.0 (0.7 to 1.4) (p = 0.89) | 1.0 (0.7 to 1.6) (p = 0.90) | 1.6 (1.3 to 2.0) (p<0.001) | 1.9 (1.2 to 3.0) (p = 0.006) | 0.8 (0.6 to 1.2) (p = 0.33) | 0.9 (0.7 to 1.1) (p = 0.21) | ||
| Born UK | 2.8 (1.1 to 7.0) (p = 0.03) | ||||||||
| White | 1 (p<0.001) | 1 (p<0.021) | 1 (p = 0.19) | 1 (p = 0.21) | 1 (p<0.001) | 1 (p = 0.03) | 1 (p = 0.21) | 1 (p<0.13) | 1 (p = 0.26) |
| South Asian | 0.4 (0.3 to 0.6) | 1.0 (0.6 to 1.6) | 1.6 (0.8 to 3.0) | 1.0 (0.5 to 2.1) | 1.1 (0.2 to 6.7) | 0.7 (0.5 to 1.1) | 1.5 (0.7 to 3.0) | 0.4 (0.2 to 0.9) | 0.6 (0.4 to 1.0) |
| Black African | 0.8 (0.5 to 1.1) | 1.3 (0.8 to 2.0) | 2.5 (1.2 to 5.7) | 1.4 (0.7 to 2.6) | 0.8 (0.1 to 7.2) | 1.1 (0.8 to 1.6) | 1.3 (0.7 to 2.6) | 0.5 (0.3 to 1.0) | 0.7 (0.5 to 1.1) |
| Black Caribbean | 1.5 (1.0 to 2.1) | 3.0 (1.2 to 7.7) | 1.6 (0.3 to 10.2) | 1.5(0.5 to 5.2) | 9.7 (2.6 to 35.4) | 1.4 (0.9 to 2.3) | 0.7 (0.3 to 1.9) | 1.0 (0.5 to 2.1) | 0.7 (0.4 to 1.6) |
| Other ethnic | 1.0 (0.7 to 1.4) | 1.9 (1.0 to 3.4) | 2.5 (0.9 to 7.1) | 1.8 (0.7 to 4.2) | 6.1 (1.6 to 23.3) | 0.8 (0.5 to 1.3) | 2.1 (0.9 to 4.9) | 0.7 (0.3 to 1.6) | 0.9 (0.6 to 1.6) |
| Previous TB | 3.0 (1.9 to 4.9) (p<0.001) | 7.8 (4.8 to 12.5) (p<0.001) | |||||||
| Problem drug users | 2.2 (1.6 to 2.9) (p<0.001) | 3.5 (1.6 to 7.7) (p = 0.001) | 2.7 (1.6 to 4.3) (p<0.001) | 1.6 (0.8 to 2.9) (p = 0.17) | 2.0 (1.2 to 3.2) (p = 0.004) | ||||
| Prison in this episode | 3.0 (1.7 to 5.5) (p<0.001) | 10.3 (4.0 to 26.5) (p<0.001) | 3.9 (2.5 to 6.1) (p<0.001) | 5.1 (2.6 to 10.3) (p<0.001) | |||||
| Hostel/street homeless | 1.6 (1.0 to 2.6) (p<0.054) | 2.0 (0.9 to 4.5) (p = 0.09) | 2.5 (1.6 to 3.7) (p<0.001) | 3.8 (2.0 to 7.4) (p<0.001) | 1.6 (0.8 to 3.1) (p = 0.16) | 2.6 (1.7 to 3.9) (p<0.001) | |||
| Ever homeless | 1.6 (1.1 to 2.2) (p<0.015) | 2.1 (1.1 to 4.1) (p = 0.028) | |||||||
| Mental health problem | 2.1 (1.3 to 3.3) (p = 0.003) | 2.1 (1.0 to 4.7) (p<0.049) | 3.1 (1.5 to 6.3) (p = 0.002) | 4.3 (2.5 to 7.3) (p<0.001) | |||||
MDRTB, multidrug resistant tuberculosis; DOT, directly observed therapy.
The table includes adjusted odds ratios for variables that remained in the regression model following backwards elimination.