Table 3 Crude and multivariate adjusted hazard ratios for ischaemic events as predicted by dichotomised concentrations (< or ⩾ median) of endothelial cell activation markers.

Variable		All ischaemic events								Spontaneous DCI
		Crude HR				Adjusted HR				Crude HR			Adjusted HR
		HR		(95% CI)		HR		(95% CI)		HR	(95% CI)		HR		(95% CI)
vWf ⩾93.0 nmol/l		2.3		(1.1 to 4.9)		1.8		(0.8 to 3.9)		3.5	(0.9 to 13.1)		2.2		(0.5 to 9.8)
vWf propeptide ⩾7.70 nmol/l		1.1		(0.6 to 2.3)		0.8		(0.4 to 1.7)		1.0	(0.3 to 3.3)		0.7		(0.2 to 2.7)
ED1‐fibronectin ⩾2.15 μg/l		1.2		(0.6 to 2.4)		0.9		(0.4 to 2.0)		1.8	(0.5 to 6.1)		1.5		(0.4 to 5.4)
sICAM‐1 ⩾376.5 ng/ml		1.0		(0.5 to 2.1)		0.9		(0.5 to 1.9)		0.9	(0.3 to 2.9)		1.3		(0.4 to 5.0)
Sp‐selectin ⩾92.5 ng/ml		1.5		(0.8 to 3.1)		1.5		(0.6 to 3.3)		1.3	(0.4 to 4.2)		0.8		(0.2 to 3.1)
sE‐selectin ⩾41.5 ng/ml		0.8		(0.4 to 1.6)		0.7		(0.3 to 1.6)		0.5	(0.1 to 1.7)		0.5		(0.2 to 1.8)

vWf: adjusted for amount of intracisternal blood, signs of acute ischaemia, loss of consciousness at the time of aneurysm rupture, day of blood sampling.

VWf propeptide: adjusted for amount of intracisternal blood, amount of intraventricular blood, day of blood sampling.

ED1fn: adjusted for amount of intracisternal blood, amount of intraventricular blood, day of blood sampling, loss of consciousness a the time of aneurysm rupture.

ICAM‐1: adjusted for amount of intracisternal blood, loss of consciousness a the time of aneurysm rupture, day of blood sampling.

sP‐selectin: adjusted for amount of intracisternal blood, amount of intraventricular blood, signs of acute ischaemia, loss of consciousness at the time of aneurysm rupture, day of blood sampling.

sE‐selectin: adjusted for amount of intracisternal blood, amount of intraventricular blood, signs of acute ischaemia, loss of consciousness at the time of aneurysm rupture, day of blood sampling.

CI, confidence interval; DCI, delayed cerebral ischaemia; HR, hazard ratio; vWf, von Willebrand factor.