Table 1 Studies examining the prevalence of the LRRK2 G2019S mutation in idiopathic PD cohorts.
Reference | Case recruitment base | Ethnicity | PD cases | Controls | ||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Overall | Familial | Sporadic | ||||||||||||||||||||||||
n | Carr | Freq (%) | n | Carr | Freq (%) | n | Carr | Freq (%) | n | Carr | ||||||||||||||||
Aasly5 | Outpatient clinic | Norwegian | 435 | 9 | 2.1 | 65 | 6 | 9.2 | 370 | 3 | 0.8 | 519 | 0 | |||||||||||||
Berg6 | N/A | N/A | 390 | 1 | 0.3 | 53 | 0 | <1.8 | 337 | 1 | 0.3 | 1200 | 0 | |||||||||||||
Bras7 | Outpatient clinic | Portugese | 124 | 7 | 5.6 | 22 | 2 | 9.1 | 102 | 5 | 4.9 | 126 | 0 | |||||||||||||
Deng8 | N/A | North American | 326 | 4 | 1.2 | 150 | 3 | 2.0 | 176 | 1 | 0.6 | 130 | 0 | |||||||||||||
Farrer9 | Tertiary referral clinic | North American | 786 | 4 | 0.5 | 236 | 4 | 1.7 | 550 | 0 | <0.2 | 278 | 0 | |||||||||||||
Gilks10 | Tertiary referral clinic | White British | 482 | 8 | 1.7 | N/A | 3 | N/A | N/A | 5 | N/A | 345 | 0 | |||||||||||||
Hernandez11 | N/A | Whiite North American | 719 | 7 | 1.0 | N/A | 1 | N/A | N/A | 6 | N/A | 2680 | 0 | |||||||||||||
Kay12 | Tertiary referral clinic | North American (95% white) | 1425 | 18 | 1.3 | 329 | 10 | 1.9 | 1096 | 8 | 0.7 | 1647 | 1 | |||||||||||||
Zabetian13 | Outpatient/research clinic | North American (93% European) | 371 | 3 | 0.8 | 74 | 1 | 1.4 | 297 | 2 | 0.7 | 281 | 0 | |||||||||||||
Tan17 | Tertiary referral clinic | Asian† | 675 | 0 | <0.1 | 58 | 0 | <1.7 | 617 | 0 | <0.2 | 325 | 0 | |||||||||||||
Skipper18 | Tertiary referral clinic | Asian‡ | 630 | 0 | <0.1 | 160* | 0 | <0.6 | 470 | 0 | <0.2 | 630 | 0 | |||||||||||||
Bialecka19 | Outpatient clinic | Polish | 174 | 0 | <0.5 | 21 | 0 | <4.7 | 153 | 0 | <0.7 | 190 | 0 | |||||||||||||
This study | Community/research clinic | White British | 519 | 2 | 0.4 | 74 | 1 | 1.4 | 445 | 1 | 0.2 | 887 | 0 |
*Non‐dominant family history; †88% Chinese, 7% Malay, 5% Indian; ‡84% Chinese, 8% Malay, 2% mixed Asian; Carr, carriers; Freq, frequency; N/A, not applicable.