Figure 4.

Glucocorticoid inhibition of the leukoregulin-induced expression of the ANPs. Confluent cultures of orbital fibroblasts were incubated in the presence or absence of leukoregulin (1 unit/ml) for 15 hr. Some cultures also received dexamethasone (10 nM) without or with RU38486 (100 nM). Encircled are the three prominent acidic ANPs demonstrated in Fig. 1.