Table 2 Trial appreciation.

	HAMLET (n = 28) (n (%))	PAIS (n = 30) (n (%))	p Value
Was the information provided clear to you?*
Yes	27 (96)	14 (47)	<0.001
No	0 (0)	1 (3)
Don't know	1 (4)	15 (50)
Did you perceive the outcome of treatment allocation as a matter of life or death?*
Yes	23 (82)	10 (33)	0.001
No	4 (14)	16 (54)
Don't know	1 (4)	4 (13)
Do you have negative feelings about the informed consent procedure?*
Yes	9 (32)	1 (3)	0.014
No	18 (64)	28 (94)
Don't know	1 (4)	2 (3)
Do you feel that the question for participation and randomisation was acceptable at that moment?
Yes	19 (68)	16 (54)	0.40
No	4 (14)	4 (13)
Don't know	5 (18)	10 (33)
Were you capable of deciding about participation?*
Yes	17 (61)	13 (43)	0.018
No	8 (29)	4 (14)
Don't know	3 (10)	13 (43)
Did you feel participation was voluntary?
Yes	18 (65)	23 (77)	0.18
No	8 (28)	3 (10)
Don't know	2 (7)	4 (13)
Do you regret having given permission?
Yes	3 (11)	0 (0)	0.12
No	23 (82)	25 (83)
Don't know	2 (7)	5 (17)
Are you glad with the treatment your relative received?
Yes	14 (50)	19 (63)	0.17
No	5 (18)	7 (23)
Don't know	9 (32)	4 (13)
Would you have preferred the doctor having taken the responsibility for treatment choices?
Yes	11 (39)	6 (20)	0.12
No	15 (54)	17 (57)
Don't know	2 (7)	7 (23)
Would you have preferred the doctor having taken the responsibility for study participation?
Yes	3 (11)	0 (0)	0.063
No	21 (75)	20 (67)
Don't know	4 (14)	10 (33)
Would you approve participation again under similar circumstances?
Yes	17 (61)	20 (67)	0.78
No	2 (7)	1 (3)
Don't know	9 (32)	9 (30)
How do you feel about being interviewed again?
Positive	23 (82)	23 (77)	0.49
Negative	3 (11)	2 (7)
Neutral	2 (7)	5 (17)

HAMLET, Hemicraniectomy After Middle cerebral artery infarction with Life‐threatening Edema Trial; PAIS, Paracetamol (Acetaminophen) In Stroke trial.

*Statistically significant difference between HAMLET and PAIS.