Table 1 Synopsis of the regional decreases of grey matter and white matter volumes.
| Anatomical localisation | MNI coordinates (mm) | p (FDR corrected) | T | No of voxels | |||
|---|---|---|---|---|---|---|---|
| Region | Hem | x | y | z | |||
| Grey matter | |||||||
| Inferior temporal gyrus | L | –54 | –19 | –30 | 0.012 | 6.47 | 1379 |
| Middle temporal gyrus | L | –47 | –67 | 8 | 0.012 | 6.15 | 437 |
| Orbital gyrus | L | –33 | 42 | –24 | 0.013 | 5.64 | 664 |
| Orbital gyrus | R | 16 | 28 | –25 | 0.013 | 5.63 | 1574 |
| Superior frontal gyrus | R | 9 | 30 | 58 | 0.014 | 5.41 | 730 |
| Superior occipital gyrus | L | –43 | –78 | 26 | 0.014 | 5.38 | 493 |
| Limbic lobe | R | 14 | –1 | –22 | 0.016 | 5.22 | 468 |
| Anterior cingulum | R | 1 | 33 | –5 | 0.017 | 5.07 | 643 |
| Superior frontal gyrus | R | 22 | 17 | 65 | 0.020 | 4.88 | 436 |
| Cerebellum | L | –34 | –43 | –45 | 0.025 | 4.11 | 596 |
| White matter | |||||||
| Frontal lobe (medial inferior) and brainstem | L | –30 | 26 | –16 | 0.000 | 8.23 | 102 432 |
| Cerebellum (medial) | L | –12 | –71 | –26 | 0.000 | 6.40 | 23 260 |
| Frontal lobe (medial) | R | 12 | 56 | 16 | 0.001 | 6.05 | 2253 |
| Temporal/occipital lobe | R | 40 | –55 | 17 | 0.002 | 4.74 | 1358 |
| Parietal lobe (near cingulum) | R | 2 | –55 | 27 | 0.003 | 4.40 | 4341 |
| Frontal lobe (mediofrontal) | R | 12 | 45 | –10 | 0.005 | 4.08 | 2656 |
| Frontal lobe (near precentral) | L | –29 | –22 | 50 | 0.009 | 3.77 | 691 |
| Temporal lobe (near fusiform) | R | 40 | –51 | –12 | 0.011 | 3.68 | 684 |
FDR, false discovery rate; Hem, hemisphere; MNI, Montreal Neurological Institute stereotaxic atlas.
Anatomical areas of grey matter and white matter regional atrophy, their localisation within the standardised stereotaxic atlas, their significance levels (expressed as p values and T scores) and the size of the atrophic areas (expressed as number of voxels) compared with healthy controls (thresholded at p<0.05, corrected for multiple comparisons).