Table 2 Structural measurements in patients with hippocampal sclerosis in relation to mood state.
| Major depression | No depression | |
|---|---|---|
| n | 15 | 19 |
| Volumetrics | ||
| Hippocampus | ||
| Ipsi | 64 (13) | 71 (18) |
| Contra | 93 (18) | 97 (17) |
| Amygdala | ||
| Ipsi | 76 (19) | 76 (19) |
| Contra | 71 (21) | 80 (21) |
| T2 relaxometry | ||
| Hippocampus | ||
| Ipsi | 117 (15) | 120 (10) |
| Contra | 102 (7) | 102 (6) |
| Amygdala | ||
| Ipsi | 102 (15) | 105 (9) |
| Contra | 97 (10) | 103 (8)* |
Volumes and T2 relaxation times are expressed as a percentage of normal values based on control values obtained in subjects of the same gender. Differences between depressed and non‐depressed patients were assessed by ANCOVA, with age and total brain volume included as covariates for the volumetric measurements, and age for the T2 relaxation times.
*Only patients without depression had a contralateral T2 increase in the amygdala.